Transcript
BIOLOGY 1511 HONORS BIOLOGICAL PRINCIPLES FALL 2011 Page 1 BIOLOGY 1511 HONORS BIOLOGICAL PRINCIPLES FALL 2011 p. 1 of 7 Lecture Faculty: Jennifer K. Leavey (JKL) 474-C Clough Undergraduate Learning Center tel: 404-385-7229 email: jennifer.leavey@biology.gatech.edu Joseph P. Montoya (JPM) 1244 EST Building tel: 404-385-0479 email: montoya@gatech.edu Lab Faculty: Cara Gormally 474-D Clough Undergraduate Learning Center tel: 404-385-2762 email: cara.gormally@biology.gatech.edu Prerequisites: A score of 4 or 5 on the AP Biology test or permission of the instructors. Description: This is an active-learning class that introduces students to basic principles of modern biology, including biomacromolecules, bioenergetics, cell structure, genetics, homeostasis, evolution, and ecological relationships. This course will foster the development of critical scientific skills including hypothesis testing, experimental design, data analysis and interpretation, and scientific communication. This course is intended for students with a strong background and interest in biology and includes a greater emphasis on current research and recent advances in biology than Biology 1510. Textbook: Campbell, N.A. et al. (2008). Biology, 8th Edition. Benjamin Cummings, San Francisco. We have arranged special pricing through the bookstore for hardcover, looseleaf-bound and ebook versions of the textbook bundled with access to the Mastering Biology website. Clicker: A TurningPoint "clicker" is required for quizzes and interactive lecture sessions, which will contribute to the "participation" portion of your course grade. Organization: The course is organized into five modules, each of which deals with a major area of modern biology. Honor Code: All students are expected to abide by the Academic Honor Code, which can be viewed online at http://www.honor.gatech.edu. Lectures: MWF 9:05 - 9:50 in CULC 102. Attendance in lecture correlates strongly with performance in Biology 1511. We will make our lectures available via T-Square and urge you to download and print them for use in taking notes during lecture. Computers may be used in class only for group work; please plan on taking notes by hand. The lectures and readings are complementary and some materials will be presented only in lecture. Please complete each reading assignment before class. Lecture Exams: Four midterm exams and the final exam. The midterm exams will be held in the evening in CULC 102, are closed-book and will be made up of multiple-choice and short-essay questions based on topics, materials, and discussions presented in class, in the assigned readings, and on MasteringBiology.com. Exams and quizzes may also be given in the laboratory and on-line via Mastering Biology and T-square. Page 2 BIOLOGY 1511 HONORS BIOLOGICAL PRINCIPLES FALL 2011 p. 2 of 7 Missed Exams: If you miss an exam for any reason, you will receive a grade of 0 (zero) on that exam unless you petition us for a makeup exam within 24 h of the start of the missed exam, and we approve your petition. Your petition must be submitted in writing and must include documentation of a legitimate reason for missing the exam. You can, of course, submit your petition before the exam if you know of your scheduling conflict in advance. We will consider each petition individually. Examples of legitimate reasons to miss an exam include illness, illness or death in your immediate family, and participation in official university activities. If we approve your petition, we will remove the missed exam from your grade calculation by using the weighted mean of your other exam scores as your grade for the missed exam, making it completely neutral in your final point total. You may also petition for a makeup exam. If we accept your petition, we will administer a makeup exam before the end of the term. Quizzes: Short quizzes may be administered in lecture, lab and online. Group Projects: Groups of 4 students will work together as Discussion Leaders to put together clear concise presentations related to two topics in the lecture syllabus. All four group members are expected to work together in putting together each presentation, but each member is expected take part in just one of the in-class presentations. You should be creative in your use of learning aids and we will guide you in the process of assembling an effective presentation. Your score will be based on evaluations by your fellow students as well as input on your contribution from other group members. Labs: Laboratory attendance is mandatory and each unexcused absence will lower your final grade by 5%. We cannot accommodate makeup labs and will consider requests for excused absences from lab on a case-by-case basis. Legitimate reasons to miss a lab include illness, illness or death in the immediate family, and participation in official university activities. All such requests must be submitted in writing with appropriate documentation (e.g., a letter from a physician or the athletic department) no later than the day after the missed lab. Bonus Points: We will provide two opportunities to earn bonus points which (if earned) will be added to your lowest exam grade. You may attempt either or both opportunities once during the semester for up to four points added to your lowest exam score. We will consider both the content and writing (spelling, grammar, punctuation, and style) in assigning 0, 1, or 2 bonus points to your effort. 1. We will post podcasts from Nature.com, NakedScientists.com, and Science.com on T-Square. Choose one, listen to it, and write a one-page paper following any one of the following formats: a. Critical review: critique the podcast at a level appropriate for an audience of scientists. b. Opinion piece: write a paper either supporting or criticizing the podcast at a level appropriate for an educated reader who is not a scientist. c. Popular summary: summarize the podcast for a lay audience unfamiliar with biology. 2. Visit the Georgia Aquarium, the Atlanta Zoo, the Atlanta Botanical Garden, the Fernbank Museum, or the Fernbank Science Center. Write a one-page summary of your visit to describe your observations to someone who has not visited, and attach your admission receipt Page 3 BIOLOGY 1511 HONORS BIOLOGICAL PRINCIPLES FALL 2011 p. 3 of 7 Biology Minute: This is another opportunity to earn extra credit. Once during the semester, you may present an oral “minute paper,” with one PowerPoint slide, to the class. Exceptional presentations will earn two points, average presentations will receive 1 point, and inadequate presentations will receive no credit. Any Biology Minute points earned will be added to your FINAL grade. Your one-minute presentation should summarize any biologically-relevant current issue or topic from reputable news sources (newspapers such as AJC and The New York Times, journals such as Science and Nature, or popular magazines such as Scientific American). We will post a signup calendar on T-square where you can reserve a time slot. Because not everyone will be able to take advantage of this opportunity, you will have two points deducted from your final grade if you are unprepared for your chosen time. Grading: Your final grade will depend on the following combination of grades: In-class exams: 40% Final exam: 20% Group activities: 10% Participation: 10% Laboratory: 25% Note that these components total 105%, though the maximum overall score we will allow in this course is 100%. This means that class participation is effectively yet another source of extra credit toward the final grade. We will use the following procedure in calculating your final grade: 1. We will combine your exam, lab, and group activity scores into a raw composite score (0 – 100%) using the weights shown above. 2. We will use the mean score earned by the top 5% of the class as a gauge of real student performance in the class. 3. We will normalize your score to actual student performance by dividing your raw composite score by the mean score earned by the top 5% of the class. If you’re in the top 2.5% of the class, your score will be 100%. 4. We will assign final letter grades based on normalized scores using the following scale: A: ≥ 90% B: ≥ 80% and < 90% C: ≥ 70% and < 80% D: ≥ 60% and < 70% F: < 60% Page 4 BIOLOGY 1511 HONORS BIOLOGICAL PRINCIPLES FALL 2011 p. 4 of 7 Biology 1510 Module Themes and Teaching Goals Module Major theme Teaching Goals Intro • Course intro • Scientific method 1 • Evolution and Genetics • Mechanism of evolution • Mendelian genetics • DNA and genomics • Gene regulation in prokaryotes and eukaryotes 2 • Molecules, Membranes, and Metabolism • Overview of biomolecules • Introduction to bioenergetics: respiration and photosynthesis. • Chemiosmosis in respiration and photosynthesis • Diversity of metabolic pathways 3 • Ecology • Behavior and evolution • Simple population models • Community structure • Mass and energy flow through ecosystems 4 • Life on Earth • Origin of Life • Earth history • History of life on Earth • Planetary modification 5 • Current Issues in Biology • Stem cells and cloning • Immunology and evolution • Bioethics • Human health and evolution • Climate change • Course synthesis Page 5 BIOLOGY 1511 HONORS BIOLOGICAL PRINCIPLES FALL 2011 p. 5 of 7 Date Lec # Lecture Topics Readings1 Lecturer 22 Aug 01 Course overview and introductions What is science? What is the scientific method? Platt (1964) 1.3: 18-24 Both => M1 Start Module 1: Evolution & Genetics 24 Aug 02 What is life? What is evolution? An evolutionary framework for biology 22: 452-466 JPM 26 Aug 03 Mechanisms of evolution Genetic variation Mutation, drift, selection 23: 468-484 JPM 29 Aug 04 History of life on Earth Patterns of biological diversity over time Biological classification 25.3-25.6: 514-531 24.1: 487-492 JPM 31 Aug 2 Sep 7 Sep 05 06 07 Mendelian genetics Mendel’s model genetic system Monohybrid and dihybrid crosses Sex-linkage and pedigree analysis Probabilities of genetic outcomes Genetics of human disease 14: 262-277 15.1-15.3: 286-296 JKL JKL JKL 9 Sep 08 DNA as the basis of inheritance Experimental evidence for role of DNA DNA structure Semi-conservative replication of DNA 16: 305-317 JKL 12 Sep 09 Gene expression: DNA to protein Basics of transcription and translation 17: 325-348 JKL 14 Sep 10 Prokaryotic and eukaryotic genomics Genome size and organization Mammalian genomes Genome evolution 18: 351-356 21.1: 426-427 21.3-21.4: 432-438 JKL 16 Sep 11 Group Presentation 1 JKL => M2 Start Module 2: Molecules, Membranes, Metabolism 19 Sep 12 Biomolecules Small molecules Major classes of macromolecule 5: 68-89 JKL 21 Sep 13 Cellular Structure Lipid bilayer membranes Archaeal membranes Serial endosymbiosis and eukaryote evolution 6.2-6.5: 94, 98-122 JKL 22 Sep Exam 1 (evening, CULC 102) Module 1 JKL 23 Sep 14 Membrane function and transport systems Membrane composition and adaptation Membrane proteins Transport: passive diffusion, osmosis, facilitated diffusion, active transport 7: 125-139 JKL 26 Sep 15 Energetics and enzymes Thermodynamics and free energy Catalysis and kinetics, and enzymes Redox reactions Membrane potential 8: 142-159 JKL 1 Textbook readings given as Chapter #: page range in Campbell & Reese, 8th ed. Page 6 BIOLOGY 1511 HONORS BIOLOGICAL PRINCIPLES FALL 2011 p. 6 of 7 Date Lec # Lecture Topics Readings1 Lecturer 28 Sep 16 Glycolysis and fermentation Oxidation of food and reduction of an e- acceptor LUCA and prokaryotes glycolysis, substrate-level phosphorylation regeneration of NADH, fermentation 27.3: 564-565 9.1-9.2 162-169 9.5: 177-179 JKL 30 Sep 17 Cellular respiration Pyruvate oxidation Citric acid cycle Electron transport chain Chemiosmotic generation of ATP 9.3-9.4: 170-177 JKL 3 Oct 18 Eukaryote respiration Mitochondrial origins Fermentation (anaerobiosis) Amino acid and lipid breakdown Feedback regulation 9.6: 180-182 JKL 5 Oct 19 Photosynthesis Overview: reduce CO2 to organic C Pigments and light absorption Origin of photosynthesis: single PS, cyclic photophosphorylation 10.1-10.2: 185-198 JKL 7 Oct 20 Carbon fixation Evolution of PSII & noncyclic photophosphorylation Calvin-Benson cycle Energetics and stoichiometry of C fixation 10.3: 185-189 198-199 JKL 10 Oct 21 Photosynthetic strategies C3, C4, and CAM photosynthesis Recap: compare and contrast respiration & photosynthesis,mitochondria & chloroplasts. 10.4: 200-203 JKL 12 Oct 22 Group Presentation 2 JKL 13 Oct Exam 2 (evening, CULC 102) Module 2 JPM => M3 Start Module 3: Ecology 14 Oct 23 Intro to Ecology Physical Environment 52: 1148-1171 JPM 17 Oct Holiday: Fall break 19 Oct 21 Oct 24 25 Behavioral ecology Foraging and defense against predation Mate choice and sexual selection Kin selection and altruism 51.1-3: 1120-1132 51:4-5: 1133-1142 JPM JPM 24 Oct 26 Oct 26 27 Population ecology Structure, dynamics, & regulation of populations Life histories Human populations through history Population management 53: 1174-1195 JPM JPM 28 Oct 31 Oct 28 29 Community ecology Competition, Predation, parasitism, mutualism Keystone species Island Biogeography 54: 1198-1219 JPM JPM 2 Nov 4 Nov 30 31 Ecosystems Energy and material flow through ecosystems Biogeochemical cycles 55: 1222-1242 JPM JPM 7 Nov 32 Group Presentation 3 JKL Page 7 BIOLOGY 1511 HONORS BIOLOGICAL PRINCIPLES FALL 2011 p. 7 of 7 Date Lec # Lecture Topics Readings1 Lecturer => M4 Start Module 4: Life on Earth 9 Nov 33 Origin of life RNA world, Miller & Urey experiment 25.1: 507-510 TBD 11 Nov 34 Exam 3 (in class, Friday 11 Nov) Module 3 JPM 14 Nov 35 Earth History Stratigraphy, time scale, dating 25.2-25.3: 510-519 JPM 16 Nov 36 History of life on Earth Life in the remote past, Life and changes in the physical environment 25.3-25.6: 514-531 24.1: 487-492 JPM 17 Nov 37 Macroevolutionary patterns (Note: evening meeting) Radiation and extinction events Historical biogeography 22: 452-466 JPM 18 Nov 21 Nov 38 39 Human impacts on the Earth Population growth and carrying capacity Nutrients, gases, and ecosystems 53.6: 1190-1195 55.5: 1236-1242 56.1-56.3: 1245-1260 JPM JPM 23 Nov 40 Group Presentation 4 JPM 25 Nov Thanksgiving Holiday => M5 Start Module 5: Current Issues in Biology 28 Nov 41 Stem cells, cloning and bioethics 20.3-20.4: 412-423 JKL 30 Nov 42 Immunology and evolution TBD JKL 1 Dec Exam 4 (evening, CULC 102) Module 4 JPM 2 Dec 43 Human health and evolution Balancing selection Sickle cell, Thalassemia, Cystic Fibrosis TBD JPM 5 Dec 44 Infectious diseases, evolution, and society TBD JPM 7 Dec 45 Climate change TBD JPM 9 Dec 46 Course wrap-up and review Both 14 Dec Final Exam (8:00 – 10:50) (verify exam dates and times here: http://www.registrar.gatech.edu/home/calendar.php) Comprehensive
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